Impact of Mt. Olympus Honeys on Virulence Factors Implicated in Pathogenesis Exerted by Pseudomonas aeruginosa

Mount Olympus honeys exhibit significant antimicrobial activity against Pseudomonas aeruginosa, a globally concerning antibiotic-resistant pathogen. This study found that 20 honey samples from the region inhibited key virulence factors more effectively than Manuka honey, particularly at concentrations of 6% and 8% (v/v), which reduced biofilm formation to less than 20%. Sixteen honeys showed superior inhibition of elastase activity compared to Manuka honey, while 17 reduced pyoverdine production. Nearly all samples also suppressed pyocyanin production, with nine demonstrating stronger swimming motility inhibition. The research highlights the potential of Mount Olympus honeys as natural alternatives in combating P. aeruginosa-related infections.

Tsavea, E., Tzika, P., Katsivelou, E., Adamopoulou, A., Nikolaidis, M., Amoutzias, G. D., & Mossialos, D. (2023). Impact of Mt. Olympus Honeys on Virulence Factors Implicated in Pathogenesis Exerted by Pseudomonas aeruginosa. Antibiotics, 12(6), 998. https://doi.org/10.3390/antibiotics12060998